Fiona Oakley

This paper develops an ex-vivo model of hepatocellular carcinoma using precision-cut tumour slices to enable efficient and ethical drug screening.

This study shows that GKRP deficiency in mouse models reduces the long-term efficacy of the GKA AZD1656 and increases liver lipid accumulation.

This study identifies damaging LXRα mutations linked to reduced triglycerides but increased liver enzyme levels and hepatotoxicity, suggesting LXR's role in liver health and cautioning against its inhibition for MASLD treatment.

This study identifies a p62-TIF-IA axis that drives nucleolar fusion and the senescence-associated secretory phenotype (SASP) through ATM-mediated disruption of autophagic degradation.

This study shows that CLSPN, regulated by NF-κB, influences checkpoint kinase signalling and tumorigenesis, with implications for cancer treatment resistance and biomarker potential.