Author
Institute of Genetics and CancerORCID 0000-0002-7989-7329Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Bethany M Bartlett, Yatendra Kumar, Shelagh Boyle, Tamoghna Chowdhury, Andrea Quintanilla, Charlène Boumendil, Juan Carlos Acosta, Wendy A. Bickmore
The paper shows TPR is required for early NF-κB activation during oncogene-induced senescence, leading to cytoplasmic chromatin fragment formation and SASP activation.
eLife · Dec 3, 2024Peer-reviewedCell Biology
Hazel C. Thoms, Tyler S. Brant, Katie Duckett, Yizheng Yang, Jinxi Dong, Hongfei Wang, Freya Derby, Oluwatumilara Akeke, Derek A. Mann, Fraser R. Millar, Alex von Kriegsheim, Juan Carlos Acosta, Fiona Oakley, Lesley A. Stark
This study identifies a p62-TIF-IA axis that drives nucleolar fusion and the senescence-associated secretory phenotype (SASP) through ATM-mediated disruption of autophagic degradation.
bioRxiv · Dec 5, 2023 · PreprintMolecular Biology
Yee Voan Teo, Nattaphong Rattanavirotkul, Angela Salzano, Andrea Quintanilla, Núria Tarrats, Christos Kiourtis, Miryam Mueller, Anthony Richard Green, Peter D. Adams, Juan Carlos Acosta, Thomas Graham Bird, Kristina Kirschner, Nicola Neretti, Tamir Chandra
The paper identifies Notch signalling as essential for secondary senescence, distinguishing it from primary senescence through molecular endpoints.
bioRxiv · Feb 19, 2019 · PreprintGenomics