Author

Frik A. Sirgel

South African Medical Research Council

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Microbiology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Claudia SpiesiD· 1 shared David M. EngelthaleriD· 1 shared Grant TheroniD· 1 shared John Z. MetcalfeiD· 1 shared Marianna de KockiD· 1 shared Megan FolkertsiD· 1 shared Nabila A. IsmailiD· 1 shared Robin M. WarreniD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Claudia SpiesORCID

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1 paper

Recent·Most cited

MicrobiologyAntimicrobial Agents and ChemotherapyPeer-reviewedJul 21, 2025

Unpacking bedaquiline hetero-resistance: the importance of intermediate profiles for phenotypic drug-susceptibility testing

Nabila A. Ismail, Frik A. Sirgel, Shaheed Vally Omar…·Robin M. Warren

This paper shows that considering intermediate results in phenotypic drug susceptibility testing can detect bedaquiline heteroresistance at low frequencies, improving resistance determination.

9 citationstop 2%

humanbulk RNA-seq

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