Author

G. A. Cisneros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Organism:human· 3 Research Focus:protein folding & dynamics· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:mechanistic / dynamical model· 2 Assay:structural biology· 2 Organism:chicken / avian· 1

Frequent Co-Authors

B. Flath· 2 shared F. Morcos· 2 shared L. Chelico· 2 shared M. A. Hix· 2 shared A. Gaba· 1 shared B. Boysan· 1 shared B. P. Tatman· 1 shared C. D. Fage· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiochemistry

B. Flath

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in trans-acyltransferase polyketide synthases

C. D. Fage, M. Passmore, B. P. Tatman, H. G. Smith, X. Jian, U. C. Dissanayake, G. A. Cisneros, G. L. Challis, J. R. Lewandowski, M. Jenner

The paper solves the structure of an acyl hydrolase (AH) domain and investigates its mechanism for hydrolyzing short-chain thioesters on acyl carrier protein (ACP) domains in trans-AT PKSs.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Computational Compensatory Mutation Discovery Approach: Predicting a PARP1 Variant Rescue Mutation

K. Ravishankar, X. Jiang, E. M. Leddin, F. Morcos, G. A. Cisneros

This paper predicts a compensatory mutation for a PARP1 variant associated with cancer using coevolutionary analysis and molecular dynamics simulations.

bioRxiv · Nov 21, 2021Biophysics

Divergence in dimerization and activity of primate APOBEC3C

A. Gaba, M. A. Hix, S. Suhail, B. Flath, B. Boysan, D. R. Williams, T. Pelletier, M. Emerman, F. Morcos, G. A. Cisneros, L. Chelico

This study identifies the molecular basis for differences in dimerization and antiviral activity of primate APOBEC3C proteins through biochemical, virological, and computational analyses.

bioRxiv · Jul 13, 2021Biochemistry

Induced mutagenesis by the DNA cytosine deaminase APOBEC3H Haplotype I protects against lung cancer

M. A. Hix, L. Wong, B. Flath, L. Chelico, G. A. Cisneros

The paper shows that a specific APOBEC3H Haplotype I mutation destabilizes the protein, reducing its mutagenic activity and protecting against lung cancer.

bioRxiv · Feb 28, 2020 · PreprintBiophysics

Computational Investigation of O2 Diffusion Through an Intra-molecular Tunnel in AlkB; Influence of Polarization on O2 Transport

H. Torabifard, G. A. Cisneros

This study uses computational simulations to investigate O2 diffusion pathways in AlkB, finding two tunnels with one viable route and highlighting the impact of polarization and a conserved residue on O2 transport.

bioRxiv · Jun 30, 2017Biochemistry