Author

J. R. Lewandowski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Assay:structural biology· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

A. P. Kalverda· 1 shared A. Zhuravleva· 1 shared B. Chen· 1 shared B. P. Tatman· 1 shared C. D. Fage· 1 shared G. A. Cisneros· 1 shared G. Grey· 1 shared G. L. Challis· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiophysics

A. P. Kalverda

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Molecular chaperone BiP controls activity of the ER stress sensor Ire1 through interactions with its oligomers

S. Dawes, N. Hurst, G. Grey, L. Wieteska, N. V. Wright, I. W. Manfield, M. H. Hussain, A. P. Kalverda, J. R. Lewandowski, B. Chen, A. Zhuravleva

This study shows BiP directly interacts with Ire1 oligomers to regulate its activation, controlling ER stress response by modulating Ire1-LD oligomerization.

bioRxiv · Feb 16, 2024 · PreprintBiophysics

Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in trans-acyltransferase polyketide synthases

C. D. Fage, M. Passmore, B. P. Tatman, H. G. Smith, X. Jian, U. C. Dissanayake, G. A. Cisneros, G. L. Challis, J. R. Lewandowski, M. Jenner

The paper solves the structure of an acyl hydrolase (AH) domain and investigates its mechanism for hydrolyzing short-chain thioesters on acyl carrier protein (ACP) domains in trans-AT PKSs.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry