Author

X. Jian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Microbiology· 2 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. L. Challis· 2 shared M. Jenner· 2 shared P. A. Randazzo· 2 shared A. Mullins· 1 shared A. Reva· 1 shared A. Sodt· 1 shared B. P. Tatman· 1 shared C. D. Fage· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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2 shared papersBiochemistry

G. L. Challis

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Antibiotic skeletal diversification via differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases

X. Jian, F. Pang, C. Hobson, M. Jenner, L. M. Alkhalaf, G. L. Challis

The paper investigates how structural diversity in polyketide antibiotics arises through differential enoylreductase recruitment and module iteration in trans-acyltransferase polyketide synthases.

bioRxiv · Nov 30, 2023 · PreprintBiochemistry

Point mutations in Arf1 reveal cooperative effects of the N-terminal region and myristate for GTPase-activating protein catalytic activity

E. Rosenberg, X. Jian, O. Soubias, R. Jackson, E. Gladu, E. Andersen, L. Esser, A. Sodt, D. Xia, R. A. Byrd, P. A. Randazzo

The paper investigates how point mutations in Arf1 affect its interaction with GAPs, revealing cooperative effects between the N-terminal region and myristate on catalytic activity.

bioRxiv · Nov 15, 2023 · PreprintBiochemistry

Molecular basis for short-chain thioester hydrolysis by acyl hydrolase domains in trans-acyltransferase polyketide synthases

C. D. Fage, M. Passmore, B. P. Tatman, H. G. Smith, X. Jian, U. C. Dissanayake, G. A. Cisneros, G. L. Challis, J. R. Lewandowski, M. Jenner

The paper solves the structure of an acyl hydrolase (AH) domain and investigates its mechanism for hydrolyzing short-chain thioesters on acyl carrier protein (ACP) domains in trans-AT PKSs.

bioRxiv · Aug 11, 2023 · PreprintBiochemistry

Mechanistic insights into dideoxygenation in gentamicin biosynthesis

S. Li, P. d. S. Bury, F. Huang, J. Guo, G. Sun, A. Reva, C. Huang, X. Jian, Y. Li, J. Zhou, Z. Deng, F. J. Leeper, P. F. Leadlay, M. V. B. Dias, Y. Sun

The paper elucidates the dideoxygenation mechanism in gentamicin biosynthesis, showing how intermediates JI-20A and JI-20B are converted to gentamicin C complex through phosphorylation and PLP-dependent enzymatic reactions.

bioRxiv · May 12, 2021Microbiology

CIB2 regulates autophagy via Rheb-mTORC1 signaling axis

S. S. Sethna, S. L. Bernstein, X. Jian, S. Riazuddin, P. A. Randazzo, S. Riazuddin, Z. M. Ahmed

This study identifies CIB2 as a regulator of autophagy in RPE cells through the Rheb-mTORC1 signaling pathway, linking it to AMD and mTORC1-related diseases.

bioRxiv · Sep 18, 2020 · PreprintCell Biology

Discovery and biosynthesis of gladiochelins: unusual lipodepsipeptide siderophores from Burkholderia gladioli

Y. Dashti, I. Nakou, A. Mullins, G. Webster, X. Jian, E. Mahenthiralingam, G. Challis

This study identifies two novel lipodepsipeptide siderophores in Burkholderia gladioli, showing they bind ferric iron and are involved in iron acquisition.

bioRxiv · Jun 16, 2020 · PreprintMicrobiology

Microbial microdroplet culture system (MMC): an integrated platform for automated, high-throughput microbial cultivation and adaptive evolution

X. Jian, X. Guo, J. Wang, Z. L. Tan, X.-h. Xing, L. Wang, C. Zhang

The paper introduces a microbial microdroplet culture system (MMC) that enables automated, high-throughput microbial cultivation and adaptive evolution, showing improved growth rates compared to conventional methods.

bioRxiv · Dec 19, 2019Bioengineering