Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice
M. M. Zelows, C. Cady, N. Dharanipragada, A. E. Mead, Z. A. Kipp, E. A. Bates, V. Venkateshwari, R. Banerjee, S.-H. Park, N. R. Shelman, H. A. Clarke, T. R. Hawkinson, T. Medina, R. C. Sun, T. A. Lydic, , R. N. Helsley
This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.
bioRxiv · Aug 17, 2023Physiology