R. C. Sun

TgLaforin, a glucan phosphatase, reveals the dynamic role of storage polysaccharides in Toxoplasma gondii tachyzoites and bradyzoites

This study investigates the role of TgLaforin, a glucan phosphatase, in Toxoplasma gondii by showing its impact on glucan metabolism, virulence, and bradyzoite survival during chronic infection.

Pyruvate dehydrogenase kinase expression profile is a biomarker for cancer sensitivity to dichloroacetate-mediated growth inhibition.

This study identifies PDK expression profiles as a biomarker for cancer sensitivity to DCA, showing that low PDK3 expression correlates with higher DCA sensitivity.

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice

This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.

In Situ Microwave Fixation to Define the Terminal Rodent Brain Metabolome

This study uses microwave fixation to preserve brain metabolites in mice, showing reduced glucose metabolism in diabetic models and altered metabolic enzyme expression.

A cell cycle-linked mechanism for the glutamine driven establishment of stem cell fate

This study identifies a mechanism by which mitochondrial glutamine metabolism links cell cycle progression to stem cell fate decisions through PASK and WDR5 interactions.

Enhancing lifespan of budding yeast by pharmacological lowering of amino acid pools

This study shows that pharmacologically lowering amino acid pools in yeast extends lifespan by inhibiting TORC1 signaling through sphingolipid-dependent mechanisms.

Mass Spectrometry Imaging of N-Glycans Reveals Racial Discrepancies in Low Grade Prostate Tumors

This study uses mass spectrometry imaging to identify racial differences in N-glycan profiles of low-grade prostate tumors and links these differences to survival outcomes.

Compartmentalized glycogenolysis regulates lung cancer transcription

This study identifies nuclear glycogenolysis as a regulator of histone acetylation and transcription in lung cancer through malin-mediated glycogen phosphorylase translocation.

Gas-chromatography coupled mass spectrometry for rapid and sensitive quantitation of glucose and glucose phosphates derived from glycogen

The paper introduces a gas-chromatography coupled mass spectrometry method to quantify glucose and glucose phosphates in glycogen, showing higher glycogen levels in liver and more phosphate esters in skeletal muscle.