Author

R. N. Helsley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

J. M. Brown· 3 shared A. L. Brown· 2 shared B. Willard· 2 shared C. Neumann· 2 shared J. C. Garcia-Garcia· 2 shared J. T. Anderson· 2 shared K. K. Fung· 2 shared R. Banerjee· 2 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersPhysiology

J. M. Brown

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

PhysiologybioRxivAug 17, 2023

Loss of Carnitine Palmitoyltransferase 1a Reduces Docosahexaenoic Acid-Containing Phospholipids and Drives Sexually Dimorphic Liver Disease in Mice

M. M. Zelows, C. Cady, N. Dharanipragada…·R. N. Helsley

This study shows that liver-specific deletion of CPT1a in mice leads to reduced DHA-containing phospholipids and sexually dimorphic liver disease, with females showing more severe effects.

DOI 10.1016/j.molmet.2023.101815

mousebulk RNA-seq

𝕏 PostBluesky

BiochemistrybioRxivDec 31, 2021

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

R. N. Helsley, T. Miyata, A. Kadam…·J. M. Brown

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

DOI 10.7554/elife.76554

mousebulk RNA-seq

𝕏 PostBluesky

PhysiologybioRxivDec 4, 2020

Gut Microbe-Targeted Choline Trimethylamine Lyase Inhibition Improves Obesity Via Rewiring of Host Circadian Rhythms

R. C. Schugar, C. M. Gliniak, R. N. Helsley…·J. M. Brown

The paper shows that inhibiting gut microbial choline TMA-lyase reduces obesity in mice by altering microbiome composition and host circadian rhythms.

DOI 10.7554/elife.63998

mousemetabolomics

𝕏 PostBluesky