Negative trade-off between neoantigen repertoire breadth and the specificity of HLA-I molecules shapes antitumour immunity
M. Manczinger, G. Balogh, B. T. Papp, B. Koncz, L. Asztalos, L. Kemeny, B. Papp, C. Pal
The paper finds that HLA-I alleles with high peptide binding promiscuity are associated with worse prognosis in cancer patients treated with immune checkpoint inhibitors.
bioRxiv · Jun 25, 2020Cancer Biology