A short course of Tofacitinib sustains the immunoregulatory effect of CTLA4-Ig in presence of inflammatory cytokines and promotes long-term survival of murine cardiac allografts
M. Iglesias, S. Khalifian, B. C. Oh, Y. Zhang, D. Miller, S. Beck, G. Brandacher, G. Raimondi
This study shows that combining Tofacitinib with CTLA4-Ig improves cardiac allograft survival by reducing effector T cells and increasing regulatory T cells in mice.
bioRxiv · Nov 18, 2020Immunology