Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells
I. Verduci, F. Cianci, R. Cazzoli, G. Cannavale, M. Veronesi, B. Balboni, M. Ranucci, L. M. G. Palloni, C. Richichi, S. Faletti, D. Osti, G. Ailuno, G. Caviglioli, C. Tacconi, S. GIROTTO, , M. Mazzanti
This study identifies tmCLIC1 as the specific metformin receptor in glioblastoma stem cells, showing that metformin's antiproliferative effect depends on its binding to tmCLIC1 and subsequent inhibition of mitochondrial respiration.
bioRxiv · Dec 31, 2022 · PreprintCancer Biology