Author

C. Tacconi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

M. Detmar· 2 shared A. Cavalli· 1 shared A. Fantin· 1 shared B. Balboni· 1 shared C. Richichi· 1 shared D. Osti· 1 shared F. Barbieri· 1 shared F. Cianci· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

M. Detmar

Author profile →

3 papers

Recent·Most cited

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells

I. Verduci, F. Cianci, R. Cazzoli, G. Cannavale, M. Veronesi, B. Balboni, M. Ranucci, L. M. G. Palloni, C. Richichi, S. Faletti, D. Osti, G. Ailuno, G. Caviglioli, C. Tacconi, S. GIROTTO, , M. Mazzanti

This study identifies tmCLIC1 as the specific metformin receptor in glioblastoma stem cells, showing that metformin's antiproliferative effect depends on its binding to tmCLIC1 and subsequent inhibition of mitochondrial respiration.

bioRxiv · Dec 31, 2022 · PreprintCancer Biology

Lymphatic PD-L1 expression restricts tumor-specific CD8+ T cell responses

N. Cousin, S. Cap, M. Dihr, C. Tacconi, M. Detmar, L. Dieterich

This study shows that lymphatic PD-L1 limits tumor-specific CD8+ T cell responses by inducing apoptosis in central memory T cells, impacting tumor growth and immunotherapy efficacy.

bioRxiv · Oct 22, 2020Immunology

Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes

N. Fujimoto, Y. He, M. D'Addio, C. Tacconi, M. Detmar, L. C. Dieterich

The paper uses single-cell RNA sequencing to identify new markers and functions of lymphatic endothelial cell subpopulations in murine lymph nodes.

bioRxiv · Jan 9, 2020Immunology