Author

S. GIROTTO

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Cavalli· 3 shared B. Balboni· 2 shared F. Rinaldi· 2 shared R. Marotta· 2 shared A. Armirotti· 1 shared A. Fantin· 1 shared A. Gennari· 1 shared C. Richichi· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBiophysics

A. Cavalli

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Novel structural insights on full-length human RAD52: Cryo-EM and beyond

B. Balboni, R. Marotta, F. Rinaldi, S. GIROTTO, A. Cavalli

This paper presents the Cryo-EM structure of full-length human RAD52 at 2.16 Å resolution, revealing its undecameric N-terminal ring and disordered C-terminal region, with implications for inhibitor development.

bioRxiv · Apr 3, 2023 · PreprintBiophysics

Metformin antiproliferative activity is exclusively mediated by the membrane functional expression of the Chloride Intracellular Channel 1 in glioblastoma stem cells

I. Verduci, F. Cianci, R. Cazzoli, G. Cannavale, M. Veronesi, B. Balboni, M. Ranucci, L. M. G. Palloni, C. Richichi, S. Faletti, D. Osti, G. Ailuno, G. Caviglioli, C. Tacconi, S. GIROTTO, , M. Mazzanti

This study identifies tmCLIC1 as the specific metformin receptor in glioblastoma stem cells, showing that metformin's antiproliferative effect depends on its binding to tmCLIC1 and subsequent inhibition of mitochondrial respiration.

bioRxiv · Dec 31, 2022 · PreprintCancer Biology

RAD51 nuclear recruitment and inhibition towards innovative strategies against pancreatic cancer

F. Schipani, M. Manerba, R. Marotta, A. Gennari, F. Rinaldi, A. Armirotti, M. Roberti, G. Di Stefano, W. Rocchia, N. Tirelli, S. Girotto, A. Cavalli

This study investigates BRC4's role in inhibiting RAD51's nuclear recruitment and its effect on HR in pancreatic cancer cells, showing enhanced cisplatin cytotoxicity.

bioRxiv · Feb 3, 2021 · PreprintBiophysics