Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration
C. Perez-Gonzalez, G. Ceada, F. Greco, M. Matejcic, M. Gomez-Gonzalez, N. Castro, S. Kale, A. Alvarez-Varela, P. Roca-Cusachs, E. Batlle, D. M. Vignjevic, M. Arroyo, X. Trepat
This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.
bioRxiv · Sep 20, 2020Cell Biology