P. Roca-Cusachs

Optogenetic generation of leader cells reveals a force-velocity relation for collective cell migration

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.

Nucleocytoplasmic transport senses mechanics independently of cell density in cell monolayers.

The paper shows that nucleocytoplasmic transport (NCT) in cell monolayers responds to mechanical forces but not cell density, contrasting with YAP's response to both mechanics and cell density.

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

Mapping mechanical stress in curved epithelia of designed size and shape

The paper maps mechanical stress in engineered curved epithelial monolayers of controlled size and shape, showing size-independent stress increases and stress anisotropies in rectangular and ellipsoidal geometries.

Cell response to extracellular matrix energy dissipation outweighs rigidity sensing

The paper shows that substrate energy dissipation suppresses YAP mechanosensing more than stiffness cues in cell mechanotransduction.

Stiffness-dependent active wetting enables optimal collective cell durotaxis

This study shows that cellular clusters migrate optimally on stiffness gradients by balancing active traction, contractility, and surface tension, based on their wetting properties.

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

The laminin-keratin link shields the nucleus from mechanical deformation and signalling

This study shows laminin-111 shields the nucleus from mechanical deformation by linking integrin {beta}4 to keratin, affecting YAP localization and chromatin methylation in breast epithelial cells.

Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD

The paper shows mechanical cues regulate the circadian clock in fibroblasts via YAP/TAZ and TEAD, disrupting Rev-erb oscillations when YAP/TAZ translocate to the nucleus.

Mechanical strain stimulates COPII-dependent trafficking via Rac1

The paper shows mechanical strain regulates COPII-dependent ER-export through Rac1-mediated mechanotransduction.

An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion

The paper explains how E-cadherin-actin interactions mediate mechanical signals from cortical flows to inhibit epithelial cell migration based on contact orientation.

Mechanosensitivity of nucleocytoplasmic transport

Force application to the nucleus leads to nuclear accumulation of proteins by differentially affecting passive versus facilitated nucleocytoplasmic transport.

The force loading rate drives cell mechanosensing through both reinforcement and fluidization

This study shows that the rate of force application drives cell mechanosensing through reinforcement and fluidization mechanisms.

Dynamic Mechanochemical feedback between curvedmembranes and BAR protein self-organization

This study investigates how BAR proteins dynamically interact with curved membranes and how their organization depends on membrane shape and mechanical stimuli.

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.

Integrin binding dynamics modulate ligand-specific mechanosensing in mammary gland fibroblasts

This study shows that SHARPIN regulates collagen-specific mechanosensing in mammary fibroblasts by modulating integrin 11β1 activity and force transmission.

Mechanochemical feedback and control of endocytosis and membrane tension

The paper identifies a negative feedback loop between membrane tension and the CLIC/GEEC pathway mediated by vinculin and GBF1.