X. Trepat

Optogenetic generation of leader cells reveals a force-velocity relation for collective cell migration

The paper uses optogenetic Rac1 activation to generate leader cells and shows that collective cell migration requires global mechanical organization rather than autonomous leader action.

3D micropatterned traction force microscopy: a technique to control three-dimensional cell shape while measuring cell-substrate force transmission.

This paper introduces 3D-TFM to measure cell-substrate forces in 3D environments and shows cells switch from contractile to extensile behavior as volume decreases.

Nucleocytoplasmic transport senses mechanics independently of cell density in cell monolayers.

The paper shows that nucleocytoplasmic transport (NCT) in cell monolayers responds to mechanical forces but not cell density, contrasting with YAP's response to both mechanics and cell density.

Membrane to cortex attachment determines different mechanical phenotypes in LGR5+ and LGR5- colorectal cancer cells

This study identifies mechanical phenotype differences between LGR5+ and LGR5- colorectal cancer cells, linking them to membrane to cortex attachment proteins and metastatic potential.

Aging and freezing of active nematic dynamics of cancer-associated fibroblasts by fibronectin matrix remodeling

This study investigates how fibronectin matrix remodeling by cancer-associated fibroblasts (CAFs) influences their nematic dynamics, revealing aging and freezing of defect motion in the ECM.

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

Mapping mechanical stress in curved epithelia of designed size and shape

The paper maps mechanical stress in engineered curved epithelial monolayers of controlled size and shape, showing size-independent stress increases and stress anisotropies in rectangular and ellipsoidal geometries.

Stiffness-dependent active wetting enables optimal collective cell durotaxis

This study shows that cellular clusters migrate optimally on stiffness gradients by balancing active traction, contractility, and surface tension, based on their wetting properties.

Geometry-driven migration efficiency of autonomous epithelial cell clusters

This study investigates how the geometry of microstripes affects the migration efficiency of epithelial cell clusters and identifies interaction rules governing their movement in complex environments.

Caveolae couple mechanical stress to integrin recycling and activation

This study shows that caveolae regulate integrin recycling and activation in response to mechanical stress, affecting cellular mechanosensing.

The laminin-keratin link shields the nucleus from mechanical deformation and signalling

This study shows laminin-111 shields the nucleus from mechanical deformation by linking integrin {beta}4 to keratin, affecting YAP localization and chromatin methylation in breast epithelial cells.

Mechanical control of the mammalian circadian clock via YAP/TAZ and TEAD

The paper shows mechanical cues regulate the circadian clock in fibroblasts via YAP/TAZ and TEAD, disrupting Rev-erb oscillations when YAP/TAZ translocate to the nucleus.

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

The paper shows epithelial cells use a mechanical G2 checkpoint regulated by E-cadherin adhesions to control division in response to cell density changes.

A mechanosensing mechanism mediated by IRSp53 controls plasma membrane shape homeostasis at the nanoscale

The paper identifies a mechanosensing mechanism involving IRSp53 that detects and restores plasma membrane nano-scale deformations through actin polymerization.

Mechanosensitivity of nucleocytoplasmic transport

Force application to the nucleus leads to nuclear accumulation of proteins by differentially affecting passive versus facilitated nucleocytoplasmic transport.

Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction

This study shows cancer-associated fibroblasts actively compress cancer cells via actomyosin contractility, altering YAP localization and tumor morphology.

The force loading rate drives cell mechanosensing through both reinforcement and fluidization

This study shows that the rate of force application drives cell mechanosensing through reinforcement and fluidization mechanisms.

Oncogenic RAS instructs morphological transformation of human epithelia via differential tissue mechanics.

This study shows that oncogenic RAS causes morphological changes in human epithelial tissues through differential mechanics, leading to three-dimensional structures similar to cancer behaviors.

Dynamic Mechanochemical feedback between curvedmembranes and BAR protein self-organization

This study investigates how BAR proteins dynamically interact with curved membranes and how their organization depends on membrane shape and mechanical stimuli.

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.

ERK-mediated mechanochemical waves direct collective cell polarization

This study shows that ERK-mediated mechanochemical waves coordinate intercellular signaling to direct collective cell migration through long-range polarity alignment.

Intermediate filaments control collective migration by restricting traction forces and sustaining cell-cell contacts

Mechanochemical feedback and control of endocytosis and membrane tension

The paper identifies a negative feedback loop between membrane tension and the CLIC/GEEC pathway mediated by vinculin and GBF1.