M. Gomez-Gonzalez

Mapping mechanical stress in curved epithelia of designed size and shape

The paper maps mechanical stress in engineered curved epithelial monolayers of controlled size and shape, showing size-independent stress increases and stress anisotropies in rectangular and ellipsoidal geometries.

Stiffness-dependent active wetting enables optimal collective cell durotaxis

This study shows that cellular clusters migrate optimally on stiffness gradients by balancing active traction, contractility, and surface tension, based on their wetting properties.

Geometry-driven migration efficiency of autonomous epithelial cell clusters

This study investigates how the geometry of microstripes affects the migration efficiency of epithelial cell clusters and identifies interaction rules governing their movement in complex environments.

The laminin-keratin link shields the nucleus from mechanical deformation and signalling

This study shows laminin-111 shields the nucleus from mechanical deformation by linking integrin {beta}4 to keratin, affecting YAP localization and chromatin methylation in breast epithelial cells.

A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

The paper shows epithelial cells use a mechanical G2 checkpoint regulated by E-cadherin adhesions to control division in response to cell density changes.

Cancer-associated fibroblasts actively compress cancer cells and modulate mechanotransduction

This study shows cancer-associated fibroblasts actively compress cancer cells via actomyosin contractility, altering YAP localization and tumor morphology.

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration

This study maps mechanical forces in mouse intestinal organoids, revealing how stress patterns drive crypt folding and cell migration through compartmentalization.