HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics.
M. D. Surette, N. Waglechner, K. Koteva, G. D. Wright
This paper identifies HelR, a helicase-like protein that protects RNA polymerase from rifamycin antibiotics by displacing them, providing a new mechanism of resistance and guidance for antibiotic development.
bioRxiv · May 10, 2021Biochemistry