Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis
N. Kedia-Mehta, M. M. Pisarska, C. Rollings, C. O'Neill, C. DeBarra, C. Foley, N. A. Wood, N. Wrigley-Kelly, N. Veerapen, G. E. Besra, R. Bergin, N. Jones, D. O'Shea, L. V. Sinclair, A. E. Hogan
This study identifies a MYC-SLC7A5-Glycolysis metabolic axis critical for MAIT cell proliferation, showing its impairment in obesity.
bioRxiv · Jan 17, 2022 · PreprintImmunology