N. Jones

Impact of cryopreservation on immune cell metabolism as measured by SCENITH.

This study uses SCENITH to show cryopreservation affects immune cell metabolism, favoring glycolysis and impairing oxidative phosphorylation, but still allows for distinct metabolic profiling of cell subsets.

Glutamine addiction is targetable via altering splicing of nutrient sensors and epitranscriptome regulators

This study shows PRMT5 inhibition targets MNA neuroblastoma by altering splicing of nutrient sensors and epitranscriptome regulators, leading to growth inhibition and apoptosis.

Meta-metabolome ecology reveals that geochemistry and microbial functional potential are linked to organic matter development across seven rivers

The paper links geochemistry and microbial functional potential to organic matter development across seven rivers using DOM characterization, geochemical analyses, and shotgun metagenomics.

Iron deficiency in people with obesity drives defective natural killer cell mitochondrial fitness and function

This study shows that iron deficiency in people with obesity impairs NK cell mitochondrial function and cytokine production.

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

Aspirin reprogrammes colorectal cancer cell metabolism and sensitises to glutaminase inhibition

This study shows aspirin reprograms colorectal cancer cell metabolism and increases sensitivity to glutaminase inhibition, suggesting potential for improved metabolic therapies in CRC.

Identifying targetable metabolic dependencies across colorectal cancer progression

This study identifies asparagine synthesis as a metabolic vulnerability in late-stage colorectal cancer cells, showing that blocking asparagine synthetase inhibits their proliferation.

Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis

This study identifies a MYC-SLC7A5-Glycolysis metabolic axis critical for MAIT cell proliferation, showing its impairment in obesity.

A non-canonical role for glutamate decarboxylase 1 in cancer cell amino acid homeostasis, independent of the GABA shunt.

This study identifies a non-canonical role for GAD1 in cancer cell amino acid homeostasis, independent of the GABA shunt, by regulating amino acid transporter expression.

Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors.

This study identifies IL-33 as a metabolic checkpoint in RPE cells that regulates mitochondrial respiration and metabolic adaptation to immune stressors.

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

Deep analysis of the USP18-dependent ISGylome and proteome unveils important roles for USP18 in tumour cell antigenicity and radiosensitivity

This study identifies novel ISGylation targets regulated by USP18, showing its role in enhancing tumour cell antigenicity and reducing radiosensitivity in CML cells.