Author

N. Veerapen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Approach:genetic perturbation / CRISPR· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

G. S. Besra· 3 shared M. Salio· 2 shared A. Aulicino· 1 shared A. E. Hogan· 1 shared A. L. Lovering· 1 shared A. Lloyd· 1 shared A. Simmons· 1 shared A. W. Purcell· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCancer Biology

G. S. Besra

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Conserved allomorphs of MR1 drive specificity of MR1-restricted TCRs

T. V. Cornforth, N. A. Moyo, S. Cole, E. Lam, T. Lobry, R. Wolchinsky, A. Lloyd, K. Ward, E. M. Denham, G. S. Besra, N. Veerapen, P. T. Illing, J. P. Vivian, J. M. Raynes, J. Le Nours, , J. Dukes

The paper shows that MR1-restricted TCRs recognize an allelic variant of MR1 (MR1*04) present in healthy individuals, indicating that these TCRs are not cancer-specific and may react to both cancer and healthy cells.

bioRxiv · Jul 17, 2023Cancer Biology

Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis

N. Kedia-Mehta, M. M. Pisarska, C. Rollings, C. O'Neill, C. DeBarra, C. Foley, N. A. Wood, N. Wrigley-Kelly, N. Veerapen, G. E. Besra, R. Bergin, N. Jones, D. O'Shea, L. V. Sinclair, A. E. Hogan

This study identifies a MYC-SLC7A5-Glycolysis metabolic axis critical for MAIT cell proliferation, showing its impairment in obesity.

bioRxiv · Jan 17, 2022 · PreprintImmunology

The P5-ATPase ATP13A1 modulates MR1-mediated antigen presentation

C. A. Kulicke, E. De Zan, Z. Hein, C. Gonzalez-Lopez, S. Ghanwat, N. Veerapen, G. Besra, P. Klenerman, J. C. Christianson, S. Springer, S. Nijman, V. Cerundolo, M. Salio

This study identifies ATP13A1 as a key regulator of MR1 surface expression through CRISPR/Cas9 knockout experiments in human cell lines.

bioRxiv · May 26, 2021 · PreprintImmunology

African Salmonella Typhimurium sequence type 313 lineage 2 evades MAIT cell recognition by overexpressing RibB

L. Preciado-Llanes, A. Aulicino, R. Canals, P. Moynihan, X. Zhu, N. Jambo, T. Nyirenda, I. Kadwala, S. V. Owen, N. Veerapen, G. S. Besra, M. A. Gordon, J. C. D. Hinton, G. Napolitani, M. Salio, A. Simmons

The paper shows African S. Typhimurium lineage 2 strains evade MAIT cell recognition by overexpressing ribB, which may contribute to their pathogenicity.

bioRxiv · Sep 10, 2019Immunology

The hydrolase LpqI primes mycobacterial peptidoglycan recycling.

P. J. Moynihan, I. T. Cadby, N. Veerapen, M. Jankute, M. Crosatti, G. Mukamolova, A. L. Lovering, G. S. Besra

This study shows that Mycobacterium tuberculosis and M. bovis BCG recycle peptidoglycan via the LpqI enzyme, which is essential for amino sugar recycling and affects antimicrobial resistance.

bioRxiv · Jul 4, 2018Microbiology