N. A. Wood

Distinct impacts of each anti-anti-sigma factor ortholog of the chlamydial Rsb partner switching mechanism on development in Chlamydia trachomatis

This paper investigates the role of two anti-anti-sigma factors, RsbV1 and RsbV2, in the partner switching mechanism of Chlamydia trachomatis, showing that RsbV2 overexpression blocks secondary differentiation, reducing infectious EB production.

In vivo and In vitro Characterization of the ClpC AAA+ ATPase of Chlamydia trachomatis

This study characterizes the ClpC AAA+ ATPase of Chlamydia trachomatis using in vitro and in vivo approaches, revealing its essential role in chlamydial growth and identifying it as a potential target for anti-chlamydial agents.

Mucosal associated invariant T cells are altered in patients with Hidradenitis Suppurativa and contribute to the inflammatory milieu

This study shows MAIT cells are altered in Hidradenitis Suppurativa patients, with reduced frequencies and IL-17 bias, and highlights RORyt inhibition as a potential therapy.

Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis

This study identifies a MYC-SLC7A5-Glycolysis metabolic axis critical for MAIT cell proliferation, showing its impairment in obesity.

The ClpX and ClpP2 Orthologs of Chlamydia trachomatis Perform Discrete and Essential Functions in Organism Growth and Development

This study shows that ClpX and ClpP2 are essential for Chlamydia trachomatis growth and differentiation, with distinct roles in developmental cycle progression.

Initial Characterization of the Two ClpP Paralogs of Chlamydia trachomatis Suggests Unique Functionality for Each

This paper characterizes two ClpP paralogs in Chlamydia trachomatis, finding they have distinct expression, interaction, and proteolytic activity patterns.