Author

L. V. Sinclair

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 10

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 9 Approach:experimental assay· 9 Organism:human· 6 Research Focus:cell type annotation· 5 Assay:proteomics· 5 Organism:mouse· 4 Research Focus:development & morphogenesis· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

D. A. Cantrell· 4 shared A. J. Howden· 3 shared L. Spinelli· 3 shared A. E. Hogan· 2 shared C. DeBarra· 2 shared C. Rollings· 2 shared D. K. Finlay· 2 shared D. O'Shea· 2 shared

Activity by Year

2018-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

D. A. Cantrell

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Author profile →

10 papers

Recent·Most cited

Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells.

L. V. Sinclair, T. Youdale, L. Spinelli, M. Gakovic, A. J. Landlands, S. Pathak, A. J. Howden, I. Ganley, D. A. Cantrell

This study shows antigen and cytokines repress autophagy in CD8 T cells, shaping mitochondrial function, migration, and effector machinery through differential proteome pruning.

bioRxiv · Jun 10, 2024Immunology

Iron deficiency causes aspartate-sensitive metabolic and proliferative dysfunction in CD8+ T cells

M. R. Teh, N. Gudgeon, J. N. Frost, L. V. Sinclair, A. L. Smith, C. L. Millington, B. Kronsteiner, J. Roberts, B. P. Marzullo, A. E. Preston, J. Rehwinkel, T. A. Milne, D. A. Tennant, S. J. Dunachie, A. E. Armitage, , H. Drakesmith

This study shows iron deficiency impairs CD8+ T cell proliferation and metabolism by disrupting mitochondrial function, but exogenous aspartate can rescue this defect.

bioRxiv · Feb 1, 2024 · PreprintImmunology

Iron deficiency in people with obesity drives defective natural killer cell mitochondrial fitness and function

C. DeBarra, E. Ryan, M. Sugrue, O. Ryan, E. Lynn, H. M. Heneghan, C. McCarthy, P. N. Moynagh, L. V. Sinclair, N. Jones, A. Hogan, D. O Shea

This study shows that iron deficiency in people with obesity impairs NK cell mitochondrial function and cytokine production.

bioRxiv · Jan 10, 2024 · PreprintImmunology

Glycogen-fuelled metabolism supports rapid Mucosal Associated Invariant T cell responses

F. C. Cassidy, N. Kedia-Mehta, R. Bergin, A. Woodcock, A. Berisha, B. M. Bradley, E. Booth, O. K. Ryan, L. V. Sinclair, D. O'Shea, A. E. Hogan

This study shows glycogen metabolism supports rapid MAIT cell cytotoxicity and cytokine production, which may enhance their use in immunotherapy.

bioRxiv · Dec 20, 2022Immunology

QUAS-R: Glutamine (Q) Uptake Assay with Single cell Resolution reveals metabolic heterogeneity with immune populations.

L. Pelgrom, G. Davis, S. O Shaughnessy, S. I. Van Kasteren, D. K. Finlay, L. V. Sinclair

The paper introduces a single-cell assay to measure SLC1A5-mediated glutamine uptake, revealing metabolic heterogeneity in immune populations.

bioRxiv · Sep 29, 2022 · PreprintImmunology

The Immunological Proteome Resource

A. J. Brenes, J. L. Hukelmann, L. Spinelli, A. J. M. Howden, J. M. Marchingo, L. V. Sinclair, C. Rollings, O. J. James, I. R. Phair, S. P. Matthews, S. H. Ross, S. C. Arthur, M. Swamy, D. K. Finlay, A. I. I. Lamond, D. A. Cantrell

The paper introduces ImmPRes, a proteomic resource integrating mass-spectrometry data from murine hematopoietic cells to study immune activation and signaling.

bioRxiv · Aug 29, 2022Immunology

Human Mucosal Associated Invariant T cell proliferation is dependent on a MYC-SLC7A5-Glycolysis metabolic axis

N. Kedia-Mehta, M. M. Pisarska, C. Rollings, C. O'Neill, C. DeBarra, C. Foley, N. A. Wood, N. Wrigley-Kelly, N. Veerapen, G. E. Besra, R. Bergin, N. Jones, D. O'Shea, L. V. Sinclair, A. E. Hogan

This study identifies a MYC-SLC7A5-Glycolysis metabolic axis critical for MAIT cell proliferation, showing its impairment in obesity.

bioRxiv · Jan 17, 2022 · PreprintImmunology

Large Neutral Amino acid uptake and mTOR activation within CD4+ T cells coordinate Type 2 immunity and host resistance to Trichuris muris

M. Z. Krauss, K. S. Hayes, A. Villegas-Mendez, M. R. Hepworth, L. V. Sinclair, K. N. Couper, R. K. Grencis

This study shows that SLC7A5-mediated mTOR activation in CD4+ T cells is essential for effective Type 2 immunity and resistance to T. muris infection.

bioRxiv · Nov 30, 2020Immunology

Quantitative analysis of how Myc controls T cell proteomes and metabolic pathways during T cell activation

J. M. Marchingo, L. V. Sinclair, A. J. Howden, D. A. Cantrell

This study uses mass spectrometry to show Myc controls T cell proteomes and metabolic pathways by regulating amino acid transporters, which are critical for T cell activation and function.

bioRxiv · Nov 18, 2019Immunology

Antigen receptor control of methionine metabolism in T cells

L. V. Sinclair, A. J. Howden, A. J. Brenes-Murillo, L. Spinelli, J. L. Hukelmann, A. N. Macintyre, X. Liu, S. Thomson, P. M. Taylor, J. C. Rathmell, J. W. Locasale, A. I. Lamond, D. A. Cantrell

This study shows antigen receptor engagement controls methionine cycle flux and methyl donor availability for RNA and histone methylation in T cells.

bioRxiv · Dec 18, 2018Immunology