HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion
G. E. Martin, M. Pace, F. Shearer, E. Zilber, J. Hurst, J. Meyerowitz, J. P. Thornhill, J. Lwanga, H. Brown, N. Robinson, E. Hopkins, N. Olejniczak, N. Nwokolo, J. Fox, S. Fidler, , CHERUB investigators
This study finds that pre-ART HIV DNA levels predict reservoir size one year after treatment initiation during primary HIV infection, linked to CD8 T cell activation and memory expansion.
bioRxiv · Mar 17, 2019Immunology