N. Robinson

Keratinocytes Drive the Epithelial Hyperplasia Key to Sea Lice Resistance in Coho Salmon

The paper identifies keratinocyte-driven epithelial hyperplasia as the mechanism of sea lice resistance in coho salmon and highlights divergent immune responses between coho and Atlantic salmon.

Characterisation of mesenchymal stromal cells in the skin of Atlantic salmon

This study characterizes mesenchymal stromal cells in Atlantic salmon skin using single-nucleus sequencing and spatial transcriptomics, revealing their role in wound healing.

Mitochondrial translocation of TFEB regulates complex I and inflammation

This study shows TFEB regulates mitochondrial complex I and inflammation through non-transcriptional mechanisms, with implications for immune pathogenesis during infection.

Characterisation of the Ubiquitin-ESCRT pathway in Asgard archaea sheds new light on origins of membrane trafficking in eukaryotes

This study characterizes the ubiquitin-ESCRT pathway in Asgard archaea, showing its pre-eukaryotic origin and evolutionary path through gene duplication.

Cancer cells adapt FAM134B-BiP complex mediated ER-phagy to survive hypoxic stress

This study shows cancer cells use the FAM134B-BiP complex to trigger ER-phagy under hypoxia, enabling survival, and identifies vitexin as a drug that blocks this process to inhibit breast cancer.

S. Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense

This study shows S. Typhimurium disrupts macrophage glycolysis to prevent phagosome acidification and evade immune defense.

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound

The paper identifies type I interferon-associated gene expression in CD4 T cells as a predictor of delayed HIV viral rebound after antiretroviral therapy interruption.

Ranking the direct threats to biodiversity in sub-Saharan Africa

The paper ranks direct threats to biodiversity in sub-Saharan Africa using expert consensus, IUCN data, and national strategies, identifying agriculture, hunting, and logging as top threats with regional variations.

Proteasome-mediated protein degradation resets the cell division cycle and triggers ESCRT-III-mediated cytokinesis in an archaeon

This study identifies proteasome-mediated degradation of CdvB as a mechanism resetting the cell division cycle and triggering cytokinesis in the archaeon Sulfolobus acidocaldarius.

Prevalence estimate of blood doping in elite track and field at the introduction of the Athlete Biological Passport

This study estimates blood doping prevalence in elite track and field athletes using haematological parameters from the Athlete Biological Passport, finding an average prevalence of 18% in endurance athletes.

HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion

This study finds that pre-ART HIV DNA levels predict reservoir size one year after treatment initiation during primary HIV infection, linked to CD8 T cell activation and memory expansion.

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue

The paper shows HIV DNA enrichment in CD32+ CD4 T cells early in infection but finds no correlation with rebound viraemia or HIV DNA levels.