Author

S. Fidler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

H. Brown· 3 shared J. Frater· 3 shared M. Pace· 3 shared N. Robinson· 3 shared C. Willberg· 2 shared E. Hopkins· 2 shared J. Fox· 2 shared J. Meyerowitz· 2 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

H. Brown

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

A.-K. Reuschl, M. Shivkumar, D. Mesner, L. J. Pallett, J. A. Guerra-Assuncao, R. Madansein, K. J. Dullabh, A. Sigal, J. P. Thornhill, C. Herrera, S. Fidler, M. Noursadeghi, M. Maini, C. Jolly

This study shows HIV-1 infects resting memory T cells without prior activation, inducing a tissue-resident memory-like phenotype driven by Vpr.

bioRxiv · Jan 25, 2021Microbiology

Expression of type I interferon-associated genes at antiretroviral therapy interruption predicts HIV virological rebound

P. Zacharopoulou, E. Marchi, A. Ogbe, N. Robinson, H. Brown, M. Jones, L. Parolini, M. Pace, N. Grayson, P. Kaleebu, H. Rees, S. Fidler, P. Goulder, P. Klenerman, J. Frater

The paper identifies type I interferon-associated gene expression in CD4 T cells as a predictor of delayed HIV viral rebound after antiretroviral therapy interruption.

bioRxiv · Nov 24, 2020 · PreprintMicrobiology

HIV reservoir size is determined prior to ART initiation and linked to CD8 T cell activation and memory expansion

G. E. Martin, M. Pace, F. Shearer, E. Zilber, J. Hurst, J. Meyerowitz, J. P. Thornhill, J. Lwanga, H. Brown, N. Robinson, E. Hopkins, N. Olejniczak, N. Nwokolo, J. Fox, S. Fidler, , CHERUB investigators

This study finds that pre-ART HIV DNA levels predict reservoir size one year after treatment initiation during primary HIV infection, linked to CD8 T cell activation and memory expansion.

bioRxiv · Mar 17, 2019Immunology

Enrichment of the HIV reservoir in CD32+ CD4 T cells occurs early in blood and tissue

G. Martin, M. Pace, J. Thornhill, C. Phetsouphanh, J. Meyerowitz, M. Gossez, E. Hopkins, H. Brown, N. Robinson, N. Olejniczak, G. Ramjee, P. Kaleebu, K. Porter, C. Willberg, P. Klenerman, , J. Frater

The paper shows HIV DNA enrichment in CD32+ CD4 T cells early in infection but finds no correlation with rebound viraemia or HIV DNA levels.

bioRxiv · Jul 27, 2017Immunology