Somatic chromosomal number alterations affecting driver genes inform in-vitro and clinical drug response in high-grade serous ovarian cancer
F. Correia Martins, D.-L. Couturier, I. Santiago, C. Sauer, M. Vias, M. Angelova, D. Sanders, A. Piskorz, J. Hall, K. Hosking, A. Amirthanayagam, S. Cosulich, L. Carnevalli, B. Davies, T. B. K. Watkins, , J. D. Brenton
This study shows that somatic copy number alterations in driver genes correlate with drug response in HGSOC spheroid models and clinical settings.
bioRxiv · Oct 4, 2020 · PreprintCancer Biology