Author

W. T. Khaled

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:clustering· 2 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

S. Pensa· 3 shared A.-J. Twigger· 2 shared A. D. Reed· 1 shared A. Figueiredo Baptista· 1 shared A. R. Bausch· 1 shared A. Steif· 1 shared B. P. Davies· 1 shared B. W. Strugnell· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

S. Pensa

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Author profile →

4 papers

Recent·Most cited

In the murine and bovine maternal mammary gland signal transducer and activator of transcription 3 is activated in clusters of epithelial cells around the day of birth

L. J. A. Hardwick, B. P. Davies, S. Pensa, M. Burge-Rogers, C. Davies, A. Figueiredo Baptista, R. Knott, I. McCrone, E. Po, B. W. Strugnell, K. Waine, P. Wood, W. T. Khaled, H. D. Summers, P. Rees, , K. Hughes

The paper examines pSTAT3 expression in murine and bovine mammary glands around birth, finding non-random clustering of pSTAT3-positive cells in alveoli.

bioRxiv · Nov 22, 2023Cell Biology

A Human Breast Cell Atlas Mapping the Homeostatic Cellular Shifts in the Adult Breast

A. D. Reed, S. Pensa, A. Steif, J. Stenning, D. Kunz, P. He, A.-J. Twigger, K. Kania, R. Barrow, I. Goulding, J. Gomm, L. Jones, J. Marioni, W. T. Khaled

This study creates a Human Breast Cell Atlas using scRNA-seq from 55 donors, identifying 41 cell subclusters and showing how factors like age and BRCA mutations affect breast homeostasis and immune cell states.

bioRxiv · Apr 21, 2023 · PreprintCancer Biology

A strategy to address dissociation-induced compositional and transcriptional bias for single-cell analysis of the human mammary gland

L. K. Engelbrecht, A.-J. Twigger, H. M. Ganz, C. J. Gabka, A. R. Bausch, H. Lickert, M. Sterr, I. Kunze, W. T. Khaled, C. H. Scheel

The paper presents a strategy to minimize dissociation-induced biases in single-cell analysis of human mammary glands by comparing different dissociation methods using single-cell RNA sequencing and flow cytometry.

bioRxiv · Feb 11, 2021 · PreprintCell Biology

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinoma

K. A. Lazarus, F. Hadi, E. Zambon, K. Bach, M.-F. Santolla, J. K. Watson, L. L. Correia, M. Das, R. Ugur, S. Pensa, L. Becker, L. S. Campos, G. Ladds, P. Liu, G. Evan, , W. T. Khaled

This study identifies BCL11A as an oncogene in lung squamous cell carcinoma, showing its interaction with SOX2 to regulate epigenetic factors and demonstrating potential therapeutic targets.

bioRxiv · Nov 22, 2017Cancer Biology