Author

G. F. Ruda

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

P. E. Brennan· 2 shared A. Aimon· 1 shared A. Bradley· 1 shared A. C. Pike· 1 shared A. Chu· 1 shared A. Douangamath· 1 shared A. Plotnikov· 1 shared A. Quigley· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

P. E. Brennan

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2 papers

Recent·Most cited

The structural basis of fatty acid elongation by the ELOVL elongases

L. Nie, A. C. Pike, T. C. Pascoa, S. R. Bushell, A. Quigley, G. F. Ruda, A. Chu, V. Cole, D. Speedman, T. Moreira, L. Shrestha, S. M. Mukhopadhyay, N. A. Burgess-Brown, J. D. Love, P. E. Brennan, E. P. Carpenter

The paper reports the structure of the human ELOVL7 elongase, revealing its catalytic mechanism and substrate-binding sites, with implications for inhibiting VLCFA accumulation in diseases.

bioRxiv · Nov 11, 2020Biochemistry

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

bioRxiv · Oct 14, 2018Biochemistry