Author

P. P. Geurink

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

H. Ovaa· 5 shared A. Sapmaz· 2 shared D. Komander· 2 shared J. Gan· 2 shared J. N. Pruneda· 2 shared J. V. Nguyen· 2 shared T. G. Franklin· 2 shared A. Aimon· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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5 shared papersBiochemistry

H. Ovaa

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Author profile →

6 papers

Recent·Most cited

USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

J. Gan, A. Pinto-Fernandez, D. Flierman, J. J. L. L. Akkermans, D. P. O'Brien, H. Greenwood, H. C. Scott, J. Neefjes, G. Fritz, K.-P. Knobeloch, H. van Dam, B. M. Kessler, H. Ovaa, P. P. Geurink, A. Sapmaz

This study identifies USP16 as an ISG15 cross-reactive deubiquitinase that regulates metabolic pathway-related proteins during type I interferon responses.

bioRxiv · Jun 26, 2023 · PreprintBiochemistry

Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

G. D. Warren, T. Kitao, T. G. Franklin, J. V. Nguyen, P. P. Geurink, T. Kubori, H. Nagai, J. N. Pruneda

This study identifies and characterizes the deubiquitinase domain of LotA from L. pneumophila that specifically targets K6-linked poly-ubiquitin during infection.

bioRxiv · May 11, 2022Biochemistry

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry

Identification and characterization of diverse OTU deubiquitinases in bacteria

A. F. Schubert, J. V. Nguyen, T. G. Franklin, P. P. Geurink, C. G. Roberts, D. J. Sanderson, L. N. Miller, H. Ovaa, K. Hofmann, J. N. Pruneda, D. Komander

The paper identifies and characterizes OTU deubiquitinases in bacteria, showing their structural and functional similarities to human and viral OTUs.

bioRxiv · Mar 28, 2020Biochemistry

A Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos

P. P. Geurink, R. Kooij, A. Sapmaz, S. Liu, B.-T. Xin, G. M. C. Janssen, P. A. van Veelen, P. ten Dijke, H. Ovaa

This paper develops a fluorescent small-molecule probe to monitor UCHL1 activity in live cells and zebrafish embryos, showing specificity for UCHL1 over other DUBs.

bioRxiv · Nov 1, 2019Biochemistry

Rapid covalent-probe discovery by electrophile fragment screening

e. resnick, A. Bradley, J. Gan, A. Douangamath, T. Krojer, R. Sethi, A. Aimon, G. Amitai, D. Belini, J. Bennett, M. Fairhead, O. Fedorov, P. P. Geurink, J. Guo, A. Plotnikov, , N. London

This study develops a method for discovering covalent probes using electrophile fragment screening and identifies selective inhibitors for OTUB2 and NUDT7.

bioRxiv · Oct 14, 2018Biochemistry