G. G. Farias

Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells.

The paper shows stress-induced phase separation of ERES components into Sec bodies inhibits ER exit in mammalian cells, with Sec16A driving this process and its depletion from ERES causing functional inhibition.

ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability

The paper shows that ER tubules regulate lysosome transport into axons by promoting lysosome homo-fission and fission-driven translocation, with ER-lysosome contacts at a pre-axonal region facilitating this process.