N. Liv

Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

The paper investigates how impaired LAIR-1-collagen interaction in fibrosis contributes to inflammation and fibrosis, finding that dysfunctional collagen ligands and matrix metalloproteinases drive disease progression.

ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability

The paper shows that ER tubules regulate lysosome transport into axons by promoting lysosome homo-fission and fission-driven translocation, with ER-lysosome contacts at a pre-axonal region facilitating this process.

Bimodal Endocytic Probe for Three-Dimensional Correlative Light and Electron Microscopy

This paper introduces fBSA-Au, a bimodal endocytic tracer for 2D and 3D CLEM, enabling accurate registration of fluorescence to EM data with sub-200 nm precision.

Correlative Organelle Microscopy: fluorescence guided volume electron microscopy of intracellular processes

This paper introduces a targeted volume-CLEM pipeline that enables high-precision 3D correlation between fluorescence and electron microscopy data, enhancing throughput and enabling study of rare cellular events.

An Organoid for woven Bone

This study develops a 3D in vitro organoid model of woven bone formation using human bone marrow stromal cells, demonstrating osteoblast and osteocyte co-culture and mineralization.

VPS41 recessive mutation causes ataxia and dystonia with retinal dystrophy and mental retardation by inhibiting HOPS function and mTORC1 signaling

This paper identifies VPS41 mutations causing neurodegenerative disease by disrupting HOPS function and mTORC1 signaling, leading to lysosomal dysfunction and impaired autophagy.