Author

C. C. Hoogenraad

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Organism:C. elegans· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Akhmanova· 2 shared A. F. M. Altelaar· 2 shared E. A. Katrukha· 2 shared L. C. Kapitein· 2 shared M. O. Steinmetz· 2 shared R. Stucchi· 2 shared A. Pena· 1 shared A. S. van Regteren Altena· 1 shared

Activity by Year

2016-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Akhmanova

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability

N. Ozkan, M. Koppers, I. van Soest, A. van Harten, N. Liv, J. Klumperman, C. C. Hoogenraad, G. G. Farias

The paper shows that ER tubules regulate lysosome transport into axons by promoting lysosome homo-fission and fission-driven translocation, with ER-lysosome contacts at a pre-axonal region facilitating this process.

Nature Communications · Jul 23, 2021Peer-reviewedCell Biology

The mechanism of selective kinesin inhibition by kinesin binding protein.

J. Atherton, J. J. A. Hummel, N. Olieric, J. Locke, A. Pena, S. S. Rosenfeld, M. O. Steinmetz, C. C. Hoogenraad, C. A. Moores

This study identifies how kinesin binding protein selectively inhibits specific kinesins by structurally distorting their motor domains and blocking microtubule attachment.

bioRxiv · Jul 17, 2020 · PreprintBiochemistry

Cortical anchoring of the microtubule cytoskeleton is essential for neuron polarity and functioning

L. He, R. Koostra, R. Das, E. Oudejans, E. V. van Leen, J. Ziegler, S. Portegies, B. de Haan, A. S. van Regteren Altena, R. Stucchi, A. F. M. Altelaar, S. Wieser, M. Krieg, C. C. Hoogenraad, M. Harterink

The paper identifies UNC-119 as a key protein linking Ankyrin and CRMP to anchor microtubules in neurons, essential for maintaining polarity and function.

bioRxiv · Sep 26, 2019Cell Biology

MAP7 family proteins regulate kinesin-1 recruitment and activation

P. J. Hooikaas, M. Martin, T. Muhlethaler, G.-J. Kuijntjes, C. A. E. Peeters, E. A. Katrukha, L. Ferrari, R. Stucchi, D. G. F. Verhagen, W. E. van Riel, I. Grigoriev, A. F. M. Altelaar, C. C. Hoogenraad, S. G. D. Rudiger, M. O. Steinmetz, , A. Akhmanova

The paper shows that MAP7 family proteins activate kinesin-1 by enhancing its microtubule binding and processivity through transient interactions.

bioRxiv · Dec 22, 2018Cell Biology

Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots

E. A. Katrukha, M. Mikhaylova, H. X. van Brakel, P. M. van Bergen en Henegouwen, A. Akhmanova, C. C. Hoogenraad, L. C. Kapitein

This study uses quantum dots to investigate how cytoskeletal structures affect intracellular transport dynamics, revealing actin's role in suppressing microtubule remodeling and influencing diffusion rates.

bioRxiv · Nov 23, 2016Biophysics