Author

G. Gotthard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein structure prediction· 3 Assay:structural biology· 3 Organism:Arabidopsis· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1

Frequent Co-Authors

D. Ozerov· 3 shared F. Dworkowski· 3 shared P. Nogly· 3 shared A. Furrer· 2 shared D. Gashi· 2 shared D. James· 2 shared J. Standfuss· 2 shared S. Mous· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

D. Ozerov

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Author profile →

5 papers

Recent·Most cited

Fixed-target time-resolved crystallography at XFELs: the scourge of light contamination but reduced sample consumption

G. Gotthard, A. Flores-Ibarra, M. Carrillo, M. W. Kepa, T. J. Mason, D. P. Stegmann, B. Olasz, M. Pachota, F. Dworkowski, D. Ozerov, B. F. Pedrini, C. Padeste, J. H. Beale, P. Nogly

The paper validates a fixed-target delivery system for XFEL crystallography, showing reduced sample consumption and light contamination control for light-sensitive proteins.

bioRxiv · Dec 12, 2023 · PreprintBiophysics

Capturing the blue-light activated state of the Phot-LOV1 domain from Chlamydomonas reinhardtii using time-resolved serial synchrotron crystallography

G. Gotthard, S. Mous, T. Weinert, R. N. A. Maia, D. James, F. Dworkowski, D. Gashi, A. Furrer, D. Ozerov, E. Panepucci, M. Wang, G. F. X. Schertler, J. Heberle, J. Standfuss, P. Nogly

This paper reports a method to capture the blue-light activated state of the Phot-LOV1 domain using time-resolved serial synchrotron crystallography and provides structural insights into its activation cascade.

bioRxiv · Nov 6, 2023 · PreprintBiochemistry

ULTRAFAST STRUCTURAL CHANGES DIRECT THE FIRST MOLECULAR EVENTS OF VISION

T. Gruhl, T. Weinert, M. Rodrigues, C. J. Milne, G. Ortolani, K. Nass, E. Nango, S. Sen, P. J. Johnson, C. Cirelli, A. Furrer, S. Mous, P. Skopintsev, D. James, F. Dworkowski, , Scher

This study uses ultrafast crystallography to reveal how photoactivated retinal initiates structural changes in rhodopsin, leading to GPCR activation and vision.

bioRxiv · Oct 14, 2022 · PreprintBiochemistry

Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag and CLIP-tag

J. Wilhelm, S. Kuehn, M. Tarnawski, G. Gotthard, J. Tuennermann, T. Taenzer, J. Karpenko, N. Mertes, L. Xue, U. Uhrig, J. Reinstein, J. Hiblot, K. Johnsson

The paper compares the labeling kinetics and substrate specificities of HaloTag7, SNAP-tag, and CLIP-tag to guide their optimal use in bioimaging and biotechnology.

bioRxiv · Apr 13, 2021Biochemistry

Aequorea victoria’s secrets

G. G. Lambert, H. Depernet, G. Gotthard, D. T. Schultz, l. Navizet, T. Lambert, D. S. Bindels, V. Levesque, J. Nero Moffatt, A. Salih, A. Royant, N. C. Shaner

This study identifies and characterizes nine new fluorescent protein homologs from Aequorea victoria and related species, including bright GFP homologs and reversibly photochromic proteins.

bioRxiv · Jun 28, 2019Biochemistry