S. Kuehn

Environmental modulators of algae-bacteria interactions at scale

The paper investigates how environmental factors like pH, nutrient availability, and carbon source affect algae-bacteria interactions using a high-throughput microfluidic platform and statistical analysis.

Functional regimes define the response of the soil microbiome to environmental change

The paper uses microcosm experiments and modeling to identify three functional regimes governing soil microbiome responses to pH changes, revealing distinct metabolic dynamics and underlying mechanisms.

SARS-CoV-2 methyltransferase nsp10-16 in complex with natural and drug-like purine analogs for guiding structure-based drug discovery

The paper identifies ligands binding to the SARS-CoV-2 nsp10-16 complex using X-ray crystallography and reports their structures, providing insights for drug discovery.

A precision microgel platform to direct vascular morphogenesis in vitro

This paper introduces a microgel platform that precisely controls morphogen gradients to guide vascular morphogenesis in vitro.

Common types of microdebris affect the physiology of reef-building corals

The paper investigates how different types of microdebris impact the physiology of reef-building corals.

Statistical prediction of microbial metabolic traits from genomes

The paper predicts bacterial carbon utilization traits from genomes using statistical models, outperforming constraint-based models and generalizing to phylogenetically distant taxa.

Global patterns in gene content of soil microbiomes emerge from microbial interactions

The paper shows that environmental filtering alone cannot explain global patterns in soil microbiome gene content, as ecological interactions between genotypes drive observed associations with pH.

Highly pathogenic avian influenza causes mass mortality in Sandwich tern (Thalasseus sandvicensis) breeding colonies across northwestern Europe

This study reports mass mortality of Sandwich terns due to HPAI A(H5N1) in northwestern Europe, with over 17% of the breeding population dying and high chick mortality observed.

Learning the functional landscape of microbial communities

The paper introduces community-function landscapes to predict microbial community functions from strain presence/absence, showing they can be accurately trained with limited data and are broadly applicable.

Algae drive convergent bacterial community assembly when nutrients are scarce

This study shows that algae influence bacterial community assembly under nutrient scarcity, causing diverse consortia to converge to a common structure.

Kinetic and structural characterization of the self-labeling protein tags HaloTag7, SNAP-tag and CLIP-tag

The paper compares the labeling kinetics and substrate specificities of HaloTag7, SNAP-tag, and CLIP-tag to guide their optimal use in bioimaging and biotechnology.

Genomic structure predicts metabolite dynamics in microbial communities

The paper shows that genomic structure can predict metabolite dynamics in microbial communities using machine learning and consumer-resource models.

Closed microbial communities self-organize to persistently cycle carbon

The paper shows closed microbial communities of algae and bacteria self-organize to robustly cycle carbon through emergent metabolite exchange.

Evolution of generalists by phenotypic plasticity

This study shows that selection for faster migration in one sugar environment leads to phenotypic plasticity allowing faster migration in all sugars, suggesting plasticity aids in evolving generalist traits.

Higher-order interaction inhibits bacterial invasion of a phototroph-predator microbial community

The paper shows that a microbial community of algae and ciliate resists bacterial invasion through a 3-way interaction, not resource competition.

Hitchhiking, collapse and contingency in phage infections of migrating bacterial populations

The paper studies phage infection dynamics in migrating bacterial populations and identifies a phage transition where bacteria shift from outrunning phages to evolving resistance.

Environment determines evolutionary trajectory in a constrained phenotypic space

The paper shows that environmental constraints shape evolutionary trajectories in Escherichia coli by mediating trade-offs between swimming speed and growth rate through antagonistic pleiotropy.