Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
G. Krainer, T. J. Welsh, J. A. Joseph, J. R. Espinosa, S. Wittmann, E. de Csillery, A. Sridhar, Z. Toprakcioglu, G. Gudiskyte, M. A. Czekalska, W. E. Arter, P. St George-Hyslop, A. A. Hyman, R. Collepardo-Guevara, S. Alberti, T. P. Knowles
The paper shows that proteins forming liquid condensates can reenter a phase-separated state at high salt concentrations due to hydrophobic and non-ionic interactions, distinct from low-salt electrostatic-driven phase separation.
Nature Communications · Feb 17, 2021Peer-reviewedBiophysics