Author

Z. Toprakcioglu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

M. Vendruscolo· 3 shared T. P. J. Knowles· 3 shared F. S. Ruggeri· 2 shared G. Krainer· 2 shared T. Knowles· 2 shared A. A. Hyman· 1 shared A. Jayaram· 1 shared A. Kamada· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiophysics

M. Vendruscolo

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Aggregation of the Amyloid-beta Peptide (Abeta40) within Condensates Generated through Liquid-Liquid Phase Separation

O. M. Morris, Z. Toprakcioglu, A. Roentgen, M. Cali, T. Knowles, M. Vendruscolo

This study shows that A{beta}40 can undergo liquid-liquid phase separation and that this process enhances amyloid fibril formation in Alzheimer's disease.

bioRxiv · Dec 23, 2023Biophysics

Nanoscale profiling of evolving intermolecular interactions in ageing FUS condensates

A. Miller, Z. Toprakcioglu, S. Qamar, P. St.George-Hyslop, F. S. Ruggeri, T. P. J. Knowles, M. Vendruscolo

This study characterizes the aging behavior of FUS condensates using microfluidic technology and surface-based techniques, revealing phase transitions and structural changes associated with material properties.

bioRxiv · Dec 21, 2023Biophysics

Selenium Silk Nanostructured Films for Antifungal and Antibacterial Treatments

Z. Toprakcioglu, E. Wiita, A. Jayaram, R. Gregory, T. Knowles

This paper develops selenium silk nanostructured films that exhibit antibacterial and antifungal properties while being biocompatible and non-cytotoxic.

bioRxiv · Dec 18, 2022 · PreprintMicrobiology

Enhanced surface nano-analytics of transient biomolecular processes

A. M. Miller, S. Chia, Z. Toprakcioglu, T. Hakala, R. Schmid, Y. Feng, T. Kartanas, A. Kamada, M. Vendruscolo, F. S. Ruggeri, T. P. J. Knowles

This paper develops a lab-on-a-chip method for analyzing biomolecular processes with high sensitivity and single molecule resolution in physiological conditions.

bioRxiv · Jul 25, 2022 · PreprintBiophysics

2-photon-fabricated nano-fluidic traps for extended detection of single macromolecules and colloids in solution

O. Vanderpoorten, A. N. Babar, G. Krainer, R. P. B. Jacquat, P. K. Challa, Q. Peter, Z. Toprakcioglu, C. K. Xu, U. F. Keyser, J. Baumberg, C. F. Kaminski, T. P. J. Knowles

This paper introduces nano-fluidic traps that increase detection times for single macromolecules and colloids in solution by providing local steric confinement.

bioRxiv · Nov 17, 2021 · PreprintBiophysics

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

G. Krainer, T. J. Welsh, J. A. Joseph, J. R. Espinosa, S. Wittmann, E. de Csillery, A. Sridhar, Z. Toprakcioglu, G. Gudiskyte, M. A. Czekalska, W. E. Arter, P. St George-Hyslop, A. A. Hyman, R. Collepardo-Guevara, S. Alberti, T. P. Knowles

The paper shows that proteins forming liquid condensates can reenter a phase-separated state at high salt concentrations due to hydrophobic and non-ionic interactions, distinct from low-salt electrostatic-driven phase separation.

Nature Communications · Feb 17, 2021Peer-reviewedBiophysics