Author

C. Metallo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2 Immunology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 5 Organism:human· 5 Organism:mouse· 4 Research Focus:metabolism & bioenergetics· 3 Assay:metabolomics· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

C. R. Green· 3 shared T. Cordes· 3 shared G. H. McGregor· 2 shared M. K. Handzlik· 2 shared R. J. Shaw· 2 shared A. B. Chan· 1 shared A. Kuhlmann-Hogan· 1 shared A. Kumar· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

C. R. Green

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Author profile →

8 papers

Recent·Most cited

p53 enables phospholipid headgroup scavenging

J. Yashinskie, X. Zhu, G. McGregor, K. Paras, B. Jackson, A. Xie, R. Koche, C. Metallo, L. Finley

This study shows p53 enables lipid headgroup recycling during senescence by increasing phosphoethanolamine supply through autophagy and lysosomal catabolism, revealing a metabolic vulnerability in p53-activated cells.

bioRxiv · Jun 7, 2024Cell Biology

Quantifying acyl-chain diversity in isobaric compound lipids containing monomethyl branched-chain fatty acids

C. R. Green, M. J. Kolar, G. H. McGregor, A. T. Nelson, M. Wallace, C. Metallo

The paper develops a method to quantify acyl-chain diversity in isobaric compound lipids using UHPLC-MS and validates it with metabolically engineered adipocytes.

bioRxiv · May 28, 2024Biochemistry

Metabolic Deficiencies Underlie Plasmacytoid Dendritic Cell Exhaustion After Viral Infection

T. T. Greene, Y. Jo, M. Macal, Z. Fang, F. S. Khatri, A. L. Codrington, K. R. Kazane, C. Chiale, E. Akbulut, S. Swaminathan, Y. Fujita, P. Fitzgerald-Bocarsly, T. Cordes, C. Metallo, D. A. Scott, E. I. Zuniga

This study identifies LDHB as a key regulator of pDC IFN-I production and metabolic capacity during viral infection, linking metabolic deficiencies to pDC exhaustion and its dual role in immunity and pathology.

bioRxiv · Feb 28, 2024 · PreprintImmunology

Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism.

G. Trieger, A. Pessentheiner, S. Purcell, C. R. Green, N. DeForest, K. Willert, A. Majithia, C. Metallo, K. Godula, P. Gordts

Journal of Biological Chemistry · May 1, 2023Peer-reviewedCell Biology

EGFR+ lung adenocarcinomas coopt alveolar macrophage metabolism and function to support EGFR signaling and growth

A. Kuhlmann-Hogan, T. Cordes, Z. Xu, K. Traina, C. Robles-Oteiza, D. Ayeni, E. M. Kwong, S. Levy, M. Nobari, G. Z. Cheng, R. J. Shaw, S. L. Leibel, C. Metallo, K. Politi, S. M. Kaech

This study shows EGFR-mutant lung adenocarcinomas exploit alveolar macrophage metabolism via GM-CSF--PPARγ signaling to support tumor growth and EGFR signaling, suggesting new therapeutic strategies combining statins and PPARγ inhibition.

bioRxiv · Apr 15, 2023 · PreprintImmunology

Inter-organelle crosstalk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress

R. S. Kuna, A. Kumar, K. A. Wessendorf-Rodriguez, H. Galvez, C. R. Green, G. H. McGregor, T. Cordes, R. J. Shaw, R. U. Svensson, C. Metallo

The paper investigates how acetyl-CoA homeostasis and lipogenesis are maintained under metabolic stress through inter-organelle crosstalk using isotope tracing in knockout cell lines.

bioRxiv · Sep 24, 2022 · PreprintBiochemistry

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

K. E. Heyden, J. L. Fiddler, Y. Xiu, O. V. Malysheva, M. K. Handzlik, W. N. Phinney, L. Stiles, S. S. Stabler, C. Metallo, M. A. Caudill, M. S. Field

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

bioRxiv · Aug 29, 2022 · PreprintBiochemistry

Daily running enhances molecular and physiological circadian rhythms in skeletal muscle

N. Casanova Vallve, D. Duglan, M. E. Vaughan, M. K. Handzlik, W. Fan, R. Yu, C. Liddle, M. Downes, J. Delezie, R. Mello, A. B. Chan, M. Pariollaud, P. Westermark, C. Metallo, R. Evans, K. A. Lamia

This study shows that daily running in mice changes their muscle circadian rhythms and improves exercise performance depending on the time of day.

bioRxiv · Oct 19, 2020Physiology