Author

P. Anastasiou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Assay:bulk RNA-seq· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

C. Moore· 4 shared E. Mugarza· 4 shared J. Downward· 4 shared M. Molina-Arcas· 4 shared S. Rana· 4 shared J. Boumelha· 3 shared A. de Castro· 2 shared F. van Maldegem· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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4 shared papersCancer Biology

C. Moore

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5 papers

Recent·Most cited

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

M. Cole, P. Anastasiou, C. Lee, C. Moore, E. Mugarza, M. Jones, K. Valand, S. Rana, E. Colliver, M. Angelova, K. Enfield, A. Magness, A. Mullokandov, G. Kelly, T. de Gruijl, , F. van Maldegem

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

bioRxiv · Apr 11, 2024Cancer Biology

Combining RASG12C(ON) inhibitor with SHP2 inhibition sensitises immune excluded lung tumours to immune checkpoint blockade: a strategy for turning cold tumours hot

P. Anastasiou, C. Moore, S. Rana, A. de Castro, M. Tomaschko, J. Boumelha, E. Mugarza, C. Blaj, S. de Carne Trecesson, R. Goldstone, J. Smith, E. Quintana, M. Molina-Arcas, J. Downward

This paper shows that combining RASG12C(ON) and SHP2 inhibitors can make cold lung tumors responsive to immune checkpoint blockade by altering the tumor microenvironment and enhancing anti-tumor immunity.

bioRxiv · Jan 15, 2024Cancer Biology

CRISPR/Cas9 screen identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer

J. Boumelha, A. de Castro, N. Bah, H. Cha, S. de Carne Trecesson, S. Rana, P. Anastasiou, E. Mugarza, C. Moore, R. Goldstone, P. East, K. Litchfield, S.-H. Lee, M. Molina-Arcas, J. Downward

The paper identifies KRAS-induced COX-2 as a driver of immunotherapy resistance in lung cancer through CRISPR/Cas9 screening and shows targeting COX-2 enhances immune checkpoint blockade efficacy.

bioRxiv · Apr 13, 2023Cancer Biology

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

E. Mugarza, F. van Maldegem, J. Boumelha, C. Moore, S. Rana, M. L. Sopena, P. East, R. Ambler, P. Anastasiou, P. R. Clavijo, K. Valand, M. Cole, M. Molina-Arcas, J. Downward

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

bioRxiv · Oct 18, 2021Cancer Biology

Preventing cancer by long-term partial Myc suppression

N. M. Sodir, L. Pellegrinet, R. M. Kortlever, Y.-W. Kwon, S. Kim, D. Garcia, A. Perfetto, P. Anastasiou, L. Brown Swigart, T. D. Littlewood, G. I. Evan

This study shows that acute Myc suppression in adult mice prevents KRasG12D-driven lung and pancreatic cancers with minimal side effects when applied metronomically.

bioRxiv · Dec 30, 2020 · PreprintCancer Biology