Long-term adaptation to galactose as a sole carbon source selects for mutations in nutrient signaling pathways
A. A. Martinez, A. Conboy, S. W. Buskirk, D. A. Marad, G. I. Lang
bioRxiv · May 17, 2022 · PreprintEvolutionary Biology
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A. A. Martinez, A. Conboy, S. W. Buskirk, D. A. Marad, G. I. Lang
bioRxiv · May 17, 2022 · PreprintEvolutionary Biology
Y. Hua, G. Vella, F. Rambow, E. Allen, A. A. Martinez, M. Duhamel, S. Junius, A. Smeets, D. Nittner, D. Laoui, S. Dimmeler, T. Hehlgans, A. Liston, G. Floris, D. Lambrechts, , G. Bergers
This paper shows that antiangiogenic immunotherapies convert postcapillary venules into high-endothelial venules that support TCF1+ T cell niches through a feed-forward loop involving CD8 and NK cells.
bioRxiv · Dec 24, 2021 · PreprintCancer Biology
S. Naulaerts, D. M. Borras, A. A. Martinez, J. Messiaen, Y. Van Herck, L. Gelens, T. Venken, I. Vanmeerbeek, S. More, J. Sprooten, O. Bechter, G. Bergers, A. Liston, S. De Vleeschouwer, B. J. Van den Eynde, , A. D. Garg
This study identifies distinct CD8+T cell states in cancer patients using multi-omics data, showing that dysfunctional states resist immunotherapy while exhausted states can be targeted with specific treatments.
bioRxiv · Nov 22, 2021Immunology