G. J. Gorbsky

Dynamic Features of Chromosomal Instability during Culture of Induced Pluripotent Stem Cells

The paper tracks chromosomal instability in iPSCs during culture, finding trisomy 12 dominance and novel structural variations acquired over time.

Four novel, immortal cell lines derived from embryos of Xenopus tropicalis

The paper describes the development of four immortal cell lines from Xenopus tropicalis embryos and characterizes their karyotype and transcriptome.

Generation and diversification of recombinant monoclonal antibodies for studying mitosis

This study develops methods to generate low-cost, high-yield recombinant monoclonal antibodies and antibody fragments for studying mitosis and other applications.

Mps1 promotes poleward chromosome movements in meiotic pro-metaphase

This study shows that Mps1 promotes poleward chromosome movements in meiotic pro-metaphase by triggering microtubule depolymerization after kinetochore attachment.

More than Two Populations of Microtubules Comprise the Dynamic Mitotic Spindle

The paper investigates mitotic spindle microtubule dynamics, finding more than two populations contribute to spindle function, challenging previous classifications.

CSAG1 Maintains the Integrity of the Mitotic Centrosome in Cells with Defective p53

The paper identifies CSAG1 as a novel mitotic component that maintains centrosome integrity, particularly in cells with defective p53.

Multiple Determinants and Consequences of Cohesion Fatigue in Mammalian Cells

This study investigates cohesion fatigue in mammalian cells, showing that it results from a balance between spindle forces and cohesion resistance, and can lead to chromosome instability.

PHOSPHATASE-REGULATED RECRUITMENT OF THE SPINDLE AND KINETOCHORE ASSOCIATED (SKA) COMPLEX TO KINETOCHORES

This study shows phosphatases PP1 and PP2A promote Ska complex recruitment to kinetochores, stabilizing microtubule attachment and opposing spindle checkpoint signaling.