Author

A. R. Tipton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

G. J. Gorbsky· 2 shared I. S. Hagemann· 2 shared N. Vemalapally· 2 shared R. Bose· 2 shared S. Li· 2 shared A. Iliuk· 1 shared B. Zhou· 1 shared C. X. Ma· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

G. J. Gorbsky

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Neratinib Synergizes with Trastuzumab Antibody Drug Conjugate or with Vinorelbine to Treat HER2 Mutated Breast Cancer Patient Derived Xenografts and Organoids.

S. Li, T. M. Primeau, M. K. Highkin, S. L. Pratt, A. R. Tipton, N. Vemalapally, J. D. Monsey, Y. Tao, J. Luo, I. S. Hagemann, C.-Y. Lin, L. D. Eli, C. X. Ma, R. Bose

The paper tests neratinib combinations with T-DM1 and vinorelbine in HER2 mutated breast cancer PDX models and organoids, finding synergistic effects that could inform clinical trials.

bioRxiv · Dec 19, 2023 · PreprintCancer Biology

Breast cancer mutations HER2 V777L and PIK3CA H1047R activate the p21/CDK4/6/Cyclin D1 axis driving tumorigenesis and drug resistance.

X. Cheng, Y. Sun, M. Highkin, N. Vemalapally, X. Jin, B. Zhou, J. L. Prior, A. R. Tipton, S. Li, A. Iliuk, S. Achilefu, I. S. Hagemann, J. R. Edwards, R. Bose

This study investigates how HER2 V777L and PIK3CA H1047R mutations drive breast cancer tumorigenesis and drug resistance, showing effective combination therapies.

bioRxiv · Nov 9, 2022 · PreprintCancer Biology

Mps1 promotes poleward chromosome movements in meiotic pro-metaphase

R. E. Meyer, A. R. Tipton, G. J. Gorbsky, D. Dawson

This study shows that Mps1 promotes poleward chromosome movements in meiotic pro-metaphase by triggering microtubule depolymerization after kinetochore attachment.

Molecular Biology of the Cell · May 1, 2021Peer-reviewedCell Biology

More than Two Populations of Microtubules Comprise the Dynamic Mitotic Spindle

A. R. Tipton, G. J. Gorbsky

The paper investigates mitotic spindle microtubule dynamics, finding more than two populations contribute to spindle function, challenging previous classifications.

bioRxiv · Apr 7, 2021Cell Biology