J. D. Wren

A NOVEL UNBIASED SEED-BASED RNAi SCREEN IDENTIFIES SMALL RNAs THAT INHIBIT ANDROGEN SIGNALING AND PROSTATE CANCER CELL GROWTH

Blocking necroptosis reduces inflammation and tumor incidence in a mouse model of diet-induced hepatocellular carcinoma

Four novel, immortal cell lines derived from embryos of Xenopus tropicalis

The paper describes the development of four immortal cell lines from Xenopus tropicalis embryos and characterizes their karyotype and transcriptome.

The NOTCH3 Downstream Target HEYL Regulates Human Airway Epithelial Club Cell Differentiation

This study identifies HEYL as a downstream target of NOTCH3 that regulates human airway epithelial club cell differentiation through in vitro and in vivo analyses.

Detecting potential reference list manipulation within a citation network

The paper identifies potential reference list manipulation by analyzing citation patterns and using the Gini Index to detect skew, estimating 16% of authors may engage in it.

SEED-MEDIATED RNA INTERFERENCE OF ANDROGEN SIGNALING AND SURVIVAL NETWORKS INDUCES CELL DEATH IN PROSTATE CANCER CELLS

The paper shows that specific small RNAs inhibit androgen signaling and induce cell death in prostate cancer cells by targeting AR-coregulatory genes through 3-UTR complementarity.

E proteins orchestrate dynamic transcriptional cascades to suppress ILC2 differentiation

This study identifies E proteins as suppressors of ILC2 differentiation by repressing a transcriptional network through upregulation of repressor genes.

Neuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina

This study shows that neural retinal-derived caveolin-1 promotes inflammation in the murine retina, as its depletion reduces cytokine production and immune cell infiltration following LPS challenge.

CSAG1 Maintains the Integrity of the Mitotic Centrosome in Cells with Defective p53

The paper identifies CSAG1 as a novel mitotic component that maintains centrosome integrity, particularly in cells with defective p53.

A Tumor Suppressor-Regulated Cell Cycle Derived Gene Signature Is Prognostic Of Recurrence Risk In Prostate Cancer

The paper develops a gene signature based on Tmeff2-regulated cell cycle genes that predicts recurrence risk in prostate cancer and outperforms existing prognostic markers.