G-quadruplex DNA drives genomic instability and represents a targetable molecular abnormality in ATRX-deficient malignant glioma
Y. Wang, J. Yang, W. H. Wu, R. Shah, C. Danussi, G. J. Riggins, K. Kannan, E. P. Sulman, T. A. Chan, J. T. Huse
This study shows ATRX deficiency in glioma causes genomic instability via G-quadruplex DNA, and G4 stabilization can be therapeutically targeted.
bioRxiv · Jun 14, 2018Cancer Biology