Preexisting mycobacterial infection modulates Candida albicans-driven pyroptosis
B. Bhatt, P. Prakhar, G. K. Lohia, R. S. Rajmani, K. N. Balaji
This study shows that preexisting Mtb infection promotes C. albicans survival by modulating macrophage pyroptosis through COP1-mediated IRF9 degradation, leading to increased fungal burden and host mortality.
bioRxiv · Aug 4, 2021Microbiology