R. S. Rajmani

This study shows Salmonella Typhimurium uses AI-2 quorum sensing to enhance acid tolerance and survival in macrophages by modulating pH-sensing systems and SPI-2 regulators.

This study shows Salmonella Typhimurium uses spermidine to resist ROS stress and rewires host polyamine metabolism, enhancing survival in macrophages, and suggests DFMO as a therapeutic option.

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

This study evaluates a novel RBD-S2 fusion immunogen that shows enhanced protection against SARS-CoV-2 and its variants in animal models.

This study shows that Salmonella modulates SIRT1 and SIRT3 to maintain its metabolism and promote pathogenesis by altering host macrophage polarization and metabolism.

This study identifies moxifloxacin-induced oxidative stress in Mycobacterium tuberculosis as a mechanism of killing, showing that reductive stress and iron contribute to ROS accumulation and drug efficacy.

This paper identifies picolinic acid as a broad-spectrum antiviral that inhibits enveloped virus entry, showing efficacy against SARS-CoV-2 and Influenza A Virus in animal models.

This paper identifies PRMT5 and YY1 as regulators of ITCH expression, which influences lipid accumulation and mycobacterial survival during infection.

This study shows that preexisting Mtb infection promotes C. albicans survival by modulating macrophage pyroptosis through COP1-mediated IRF9 degradation, leading to increased fungal burden and host mortality.

This study identifies G9a and Sirt6 as epigenetic regulators that modulate host cholesterol accumulation, supporting Mycobacterium tuberculosis survival.

This study designs a thermotolerant trimeric RBD vaccine candidate that elicits strong neutralizing antibodies against multiple SARS-CoV-2 variants in animal models.

The paper shows that aging enhances innate immune responses to bacterial infections in mice but persistent inflammation leads to host mortality.

This paper demonstrates that vanadium pentoxide nanosheets act as antioxidant nanozymes to counteract HIV-1 by modulating redox potential and inhibiting viral reactivation and Mtb proliferation.

This paper shows that Mtb's SufR senses NO via its 4Fe-4S cluster, regulates Fe-S cluster biogenesis, and supports persistence in mice.

This paper shows that the effectiveness of the β-lactam/β-lactamase inhibitor combination against Mtb depends on WhiB4-regulated redox changes, with higher mycothiol redox potential enhancing drug efficacy.