U. Kolthur-Seetharam

ATP-Binding Free Energy Simulations Reveal an Allosteric Link Between the Enzyme Active Site and Multiple Functional Protein-Protein Interaction Interfaces in Cyclin Dependent Kinase-1

The paper uses molecular dynamics simulations to show that ATP binding free energy in CDK1 is affected by acetylation at the active site and reveals non-local entropy changes linked to protein-protein interactions.

Metabolic transitions regulate global protein fatty acylation

This study shows that metabolic states like fed and fasted influence global protein fatty acylation, with glucose affecting palmitoylation and oleoylation through mitochondrial and retrograde signaling pathways.

Anticipatory Biogenesis of Hepatic Fed MicroRNAs is Regulated by Metabolic and Circadian Inputs

The paper shows that hepatic microRNAs increase during fasting to anticipate refeeding, regulated by metabolic and circadian factors, with potential therapeutic implications for metabolic diseases.

G9a and Sirtuin6 epigenetically modulate host cholesterol accumulation to facilitate mycobacterial survival

This study identifies G9a and Sirt6 as epigenetic regulators that modulate host cholesterol accumulation, supporting Mycobacterium tuberculosis survival.

Anabolic SIRT4 exerts retrograde control over TORC1 signalling by glutamine sparing in the mitochondria

This study identifies SIRT4 as an anabolic factor that activates TORC1 signalling through glutamine sparing in mitochondria, linking mitochondrial function to metabolic regulation.

Temporal gating of SIRT1 functions by O-GlcNAcylation prevents hyperglycemia and enables physiological transitions in liver

This study identifies nutrient-dependent O-GlcNAcylation of SIRT1 as a mechanism controlling hepatic metabolism and insulin signaling during fasted-to-refed transitions.

Loss of mitochondrial SIRT4 shortens lifespan and leads to a decline in physical activity

This study shows that loss of mitochondrial dSirt4 reduces lifespan and impairs physical activity in flies.