Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy
A. Comba, S. M. Faisal, P. J. Dunn, A. E. Argento, T. C. Hollon, W. Al-Holou, M. L. Varela, D. B. Zamler, G. L. Quass, P. F. Apostolides, C. Abel, C. E. Brown, P. E. Kish, A. Kahana, C. G. Kleer, , P. R. Lowenstein
The paper identifies COL1A1 as a key driver of glioma mesenchymal differentiation and invasion, showing its inhibition disrupts tumor structure and improves survival.
bioRxiv · Dec 1, 2020 · PreprintCancer Biology