Author

C. G. Kleer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:spatial transcriptomics· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Comba· 1 shared A. E. Argento· 1 shared A. Kahana· 1 shared A. Nasrazadani· 1 shared A. V. Lee· 1 shared B. Weigelt· 1 shared C. Abel· 1 shared C. E. Brown· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

A. Comba

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2 papers

Recent·Most cited

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations

O. S. Shah, A. Nasrazadani, J. Foldi, J. M. Atkinson, C. G. Kleer, P. F. McAuliffe, T. J. Johnston, W. Stallaert, E. M. Da Silva, P. Selenica, H. Dopeso, F. Pareja, D. Mandelker, B. Weigelt, J. S. Reis-Filho, , S. Oesterreich

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.

bioRxiv · Sep 9, 2023Cancer Biology

Spatiotemporal analysis of glioma heterogeneity reveals Col1A1 as an actionable 1 target to disrupt tumor mesenchymal differentiation, invasion and malignancy

A. Comba, S. M. Faisal, P. J. Dunn, A. E. Argento, T. C. Hollon, W. Al-Holou, M. L. Varela, D. B. Zamler, G. L. Quass, P. F. Apostolides, C. Abel, C. E. Brown, P. E. Kish, A. Kahana, C. G. Kleer, , P. R. Lowenstein

The paper identifies COL1A1 as a key driver of glioma mesenchymal differentiation and invasion, showing its inhibition disrupts tumor structure and improves survival.

bioRxiv · Dec 1, 2020 · PreprintCancer Biology